siRNA on and off-target [electronic resource] / Anastasia Khvorova.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. RNA interference : principles and applications: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (38 min.) : color, sound)Subject(s): Bioinformatics | MicroRNA | RNA | Small interfering RNA | Algorithms | Computational Biology | MicroRNAs | RNA Interference -- physiology | RNA, Small Interfering -- genetics | RNA, Small Interfering -- metabolism | RNA, Small Interfering -- toxicityOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: siRNA target and off-target activity -- Systematic analysis of siRNA primary function -- Effect of thermodynamic bias on siRNA activity -- Development of predictive algorithms for siRNA primary activity -- Specific and non-specific siRNA activity -- siRNA off-targeting and miRNA mechanism -- Bioinformatics in off-target prediction: seed recognition -- siRNA off-targeting impact on RNAi applications -- siRNA toxicity -- siRNA specificity.
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Mode of access: World Wide Web.