CNS drug design [electronic resource] / Quentin R. Smith.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Blood-brain barrier : understanding the regulatory gatekeeper between brain and body: ; Henry Stewart talksBiomedical & life sciences collection. Small molecule drug discovery: Publisher: London : Henry Stewart Talks, 2008Description: 1 online resource (1 streaming video file (46 min.) : color, sound)Subject(s): Blood-Brain Barrier | Brain | Central Nervous System Diseases -- drug therapy | Drug Design | Molecular Targeted TherapyOnline resources: Click here to access online | Series (Blood-brain barrier) | Series (Small molecule drug discovery) Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Central nervous system diseases -- Drug market for CNS disorders -- Traditional CNS drug targets -- Novel CNS drug targets -- Multiple obstacles for drug delivery to CNS -- Pathways for drug exchange within the CNS -- The structure of brain capillaries impedes uptake -- Measures of drug uptake and distribution in brain -- BBB permeability and solute lipid solubility -- Tissues capillary PS and 95 per cent equilibration time -- Cerebral blood flow affects drug uptake and Kin -- Initial uptake vs. steady-state distribution -- Plasma protein binding and brain drug uptake -- Brain capillary drug transporters -- Transporters and drug distribution across BBB -- "Enzymatic" blood-brain barrier -- Relation between bound and free drug -- Free drug distribution ratio at steady state -- BBB changes in pathology and disease -- Drug-like properties to cross the BBB -- Early findings in BBB drug uptake -- Measures of lipophilicity -- Passive permeability across lipid membranes -- Drug ionization -- Influence of pH on neutral fraction -- Lipinski "rule of five" -- Impact of hydrogen bonds and alkyl groups -- Positive CNS drugs -- Poor CNS drug -- in vitro measures -- In vivo measures -- Methods to improve brain uptake -- Simple rules for efflux transporters -- % drug distribution to brain -- Biologic compounds -- Brain pharmacokinetics.
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Mode of access: World Wide Web.