β2 adrenergic receptor complexes mediate localized cAMP signaling [electronic resource] / Johannes W. Hell.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Ion channels: Publisher: London : Henry Stewart Talks, 2018Description: 1 online resource (1 streaming video file (43 min.) : color, sound)Other title: Beta2 adrenergic receptor complexes mediate localized cAMP signalingSubject(s): Beta adrenoceptors | Calcium channels | Cardiovascular system -- Physiology | Cellular signal transduction | Central nervous system -- Molecular aspects | alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid | Calcium Channels, L-Type -- physiology | Cyclic AMP | Neuronal Plasticity | Neurons -- physiology | Receptors, Adrenergic, beta-2 -- metabolism | Receptors, Adrenergic, beta-2 -- physiology | Receptors, AMPA | Receptors, Glutamate | Signal Transduction -- physiologyOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Updated version of a talk first published in 2011 under the title: Beta-adrenergic receptor - ion channel signaling complexes.
Contents: Introduction to signaling by beta adrenergic receptors and the corresponding regulation of the L-type calcium channel Cav1.2 in brain and heart -- Cav1.2 signaling complex in brain -- Role of the beta2 adrenergic receptor, Cav1.2, and their association in beta adrenergic signaling in the brain and in synaptic plasticity -- Introduction to the signaling complex formed by the beta2 adrenergic receptor with the AMPA-type glutamate receptor (AMPAR) -- AMPAR signaling complex in brain -- Conclusion: formation of a functional unit between the AMPAR and Cav1.2 whose activity is driven by beta2 adrenergic stimulation to augment synaptic strength in a lasting manner.
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Mode of access: World Wide Web.