The b common (bc) family of cytokines, receptors and ligands [electronic resource] / Angel Lopez and Timothy Hercus.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Cytokines: Publisher: London : Henry Stewart Talks, 2022Description: 1 online resource (1 streaming video file (40 min.) : color, sound)Other title: Beta common (beta c) family of cytokines, receptors and ligands | β common (β c) family of cytokines, receptors and ligandsSubject(s): Autoimmunity -- physiology | Cytokines -- Physiology | Cytokines -- Receptors | Ligands (Biochemistry) | Cytokines | Granulocyte-Macrophage Colony-Stimulating Factor | Inflammation -- physiopathology | Interleukins | Ligands | Receptors, Cytokine -- physiology | Receptors, Granulocyte-Macrophage Colony-Stimulating Factor | Signal Transduction -- physiologyOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Updated version of a talk first published in 2011.
Contents: Beta common cytokines -- Excessive beta common cytokine function results in inflammatory diseases -- Function through heterodimeric receptors -- The alpha subunits have a conserved architecture -- The beta subunit -- Formation of a soluble GM-CSF receptor complex -- Key interaction between cytokine and beta common, Site 2 -- Structure of soluble GM-CSF receptor complex -- Crystal structure revealed a higher-order complex -- Key dodecamer interactions are essential for receptor signalling -- Knowledge of receptor activation mechanism contributes to inhibitor development.
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Mode of access: World Wide Web.