Towards the development of potent therapy against the Hepatitis C virus [electronic resource] / Johan Neyts.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Antivirals: Publisher: London : Henry Stewart Talks, 2011Description: 1 online resource (1 streaming video file (50 min.) : color, sound)Subject(s): Antiviral agents | Hepatitis C virus | Hepatitis C -- Treatment | Antiviral Agents | Hepacivirus | Hepatitis C -- drug therapyOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: The HCV genome and replication cycle -- Interferon development -- Ribavirin -- Antiviral and GTP depletion correlation -- Selective inhibitors of HCV replication -- The NS2 cysteine and the NS3 serine proteases -- Protease inhibitors -- The NS3 helicase as an antiviral target -- NS4A/NS3, NS4B and NS5A as antiviral targets -- The NS5B RNA dependent RNA polymerase -- Nucleoside and non-nucleoside HCV inhibitors -- Double and triple combination therapies -- Debio-025 -- Resistance to HCV inhibitors -- D320E peptide mutation effect -- Role of NS5A or NS5B in resistance -- Wild type and CypA knock down studies -- Cis-trans isomerase activity of cyclophilins.
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Mode of access: World Wide Web.