Structure and mechanism of the tyrosine kinase domain of the insulin receptor [electronic resource] / Stevan R. Hubbard.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease: Publisher: London : Henry Stewart Talks, 2007Description: 1 online resource (1 streaming video file (30 min.) : color, sound)Other title: Structure and mechanism of the tyrosine kinase domain of insulin receptorSubject(s): Protein-Tyrosine Kinases | Receptor Protein-Tyrosine Kinases | Receptor, Insulin | Signal TransductionOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Introduction to receptor tyrosine kinases (RTKs) -- general mechanisms of protein recruitment to RTKs -- Structure of the insulin receptor tyrosine kinase domain (IRK) -- Autoinhibitory mechanisms in RTKs -- Structure of the Src homology-2 (SH2) domain of APS -- Structure of the APS SH2 domain bound to IRK -- Inhibition of IRK activity by Grb14 -- Structure of the Grb14 BPS region bound to IRK -- Structure of the Grb14 SH2 domain -- Model of the interaction between Grb14 and the insulin receptor.
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Mode of access: World Wide Web.