EGFR targeted therapies in lung cancer [electronic resource] / Pasi A. Janne.
Material type:
FilmSeries: Henry Stewart talksBiomedical & life sciences collection. Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease: Publisher: London : Henry Stewart Talks, 2009Description: 1 online resource (1 streaming video file (43 min.) : color, sound)Subject(s): Cellular signal transduction | Neoplasms | Receptor Protein-Tyrosine Kinases | Signal TransductionOnline resources: Click here to access online | Series Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Lung cancer: facts and figures -- Lung cancer survival -- Lung cancer burden -- EGFR targeted therapeutics -- EGFR mutations -- Why Do EGFR inhibitors work so well in EGFR mutant cancers? -- Are EGFR TKIs better than chemotherapy? -- Emergence of resistance to EGFR TKIs -- Mechanisms of Gefitinib/Erlotinib resistance -- EGFR signaling in EGFR mutant NSCLC -- Analogous kinase mutations associated with drug resistance -- Irreversible EGFR inhibitors -- Clinical resistance is heterogeneous -- Therapeutic targeting of other oncogenes in lung cancer -- Incorporating genomics into treatment.
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Mode of access: World Wide Web.