Maintaining the silenced state of master regulatory genes during development [electronic resource] / Bob Kingston.
Material type:![Film](/opac-tmpl/lib/famfamfam/VM.png)
Animated audio-visual presentation with synchronized narration.
Title from title frames.
Contents: Gene repression in cell division -- Early homeotic gene expression patterns -- The polycomb group -- Mutants of polycomb fail to maintain repression -- Transcriptional memory -- Core functional PcG complexes -- Regulation of PRC2 in drosophila and humans -- PRC2 core subunits in humans -- Prominent modifications that can occur -- Chromodomains bind H3 tail marks -- Differential chromodomain binding -- Targeting of the PcG complexes -- Drosophila PREs are bound by PHO -- Mechanisms involved in targeting -- Mammalian HOX clusters are a key PRC1 target -- Human D11.12 is similar to fly PREs -- CpG islands and long non-coding RNAs -- Small RNAs specifying repression -- Noncoding RNAs influence chromatin structure -- Mode of repression -- How are genes silenced? -- PRC1 in compaction and ubiquitylation -- Nucleosome dynamics -- Characteristics of the compaction domain -- Gene silencing by chromatin compaction -- The SIR complex and mating type silencing -- Structural rearrangements in NCP and BAH -- Folding events in Sir3 BAH/NCP complex -- The nucleosome as a silencing machinery -- Epigenetic memory.
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Mode of access: World Wide Web.