TY  - ADVS
AU  - Bier,Ethan
TI  - Cross-genomic analysis of human disease genes
T2  - The legacy of Drosophila genetics : from 'defining the gene' to 'analyzing genome function',
PY  - 2008///
CY  - London
PB  - Henry Stewart Talks
KW  - Drosophila
KW  - genetics
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Systematic cross genomic comparison revealed that 75% of human disease genes have clear homologs in Drosophila and that approx. 30% are highly conserved sequences -- The fly is an excellent model multicellular organism for examining the mechanistic function of conserved human disease genes involved in developmental or tissue-related processes -- Normal or mutant human disease genes can be mis-expressed in the fly in localized patterns or at specific times using the GAL4-UAS mis-expression system -- Flies were used to identify candidate target proteins that are regulated by Ube3a and may contribute to Angelman syndrome -- Flies were used to examine the function and interaction of two toxins, Lethal Factor (LF) and Edema Factor (EF), that are produced by Bacillus anthracis -- LF cleaves at least two of the four Drosophila MAPKKs and inhibits the function of a third -- EF inhibits PKA dependent Hedgehog signaling in the fly wing; Access restricted to subscribers
UR  - https://hstalks.com/bs/987/
UR  - https://hstalks.com/bs/p/283/
ER  -