TY  - ADVS
AU  - Peltonen,Leena
TI  - Use of isolated populations in disease gene identification
T2  - Genetic epidemiology II : latest developments,
PY  - 2007///
CY  - London
PB  - Henry Stewart Talks
KW  - Genetic Predisposition to Disease
KW  - epidemiology
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Disease mutations in Finland - Molecular background of Finnish disease heritage - Finnish disease genes, novel pathways exposed - Example: APECED - AIRE protein - AIRE regulates ectopic expression in thymus - AIRE deficiency - Simplifying the complex genetic background of common diseases - Advantages of isolated populations - Internal isolates: increased genetic homogeneity - Lactose intolerance - Adult type hypolactasia - Severe coronary heart disease - Familial combined hyperlipidemia, FCHL - USF1: a transcription factor - Effect of genetic association on target cells, coronary wall and impact in population - Population based cohorts in Finland - Global effort is needed; Access restricted to subscribers
UR  - https://hstalks.com/bs/607/
UR  - https://hstalks.com/bs/p/26/
ER  -