TY - ADVS AU - Davis,Thomas P. TI - Blood brain barrier in health and disease T2 - The blood-brain barrier : understanding the regulatory gatekeeper between brain and body, PY - 2008/// CY - London PB - Henry Stewart Talks KW - Blood-Brain Barrier KW - Brain Diseases KW - therapy KW - Brain N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: The blood-brain barrier is not a static barrier -- The blood-brain barrier does inhibit drug delivery to the brain -- The blood-brain barrier is at the level of the endothelial cell cytoarchitecture that line all cerebral blood vessels in the brain -- The blood-brain barrier consists of a unique set of regulated proteins held together in a tight cytoarchitectural matrix to form a tight junction -- Stressors such as head injury, hypoxia, pain and diseases such as M.S, diabetes, Alzheimer's, cancer and stroke alter tight junction proteins of the blood-brain barrier leading to a "leak" and a loss of integrity -- Understanding what controls the integrity of the blood-brain barrier is critical if we are to understand how to treat the diseases of the brain; Access restricted to subscribers UR - https://hstalks.com/bs/766/ UR - https://hstalks.com/bs/p/277/ ER -