TY - ADVS AU - Traktman,Paula TI - Poxviruses: Smallpox (variola), Vaccinia and Monkeypox T2 - Viruses and viral diseases : emerging threats to humans and animals, PY - 2007/// CY - London PB - Henry Stewart Talks KW - Monkeypox KW - Poxviridae KW - Risk Factors KW - Smallpox KW - Vaccinia KW - Virus Diseases KW - Viruses N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Poxvirus life cycle: chromosome structure, virion structure and virion entry -- Viral proteins needed for entry and mechanism of entry of EV (enveloped virion) -- Gene expression of EV: early transcription, intermediate and late transcription -- Working model of Poxvirus genome replication -- Morphogenesis of EV -- Key features of the IV to MV (mature virions) transition -- Poxviruses encode a three-protein complex that generates disulfide bonds in the cytoplasm -- Formation of EEV (extracellular enveloped virions) and EV mediators of cell-to-cell and distal spread -- Poxviruses encode a large array of immunomodulators -- Models for the study of Poxvirus pathogenesis -- Smallpox (Variola virus) and smallpox disease -- Pathogenicity of Variola virus vs. Vaccinia virus -- Official declaration of the eradication of smallpox -- Monkeypox virus -- Antiviral therapy and new vaccines for Poxviruses; Access restricted to subscribers UR - https://hstalks.com/bs/364/ UR - https://hstalks.com/bs/p/41/ ER -