TY - ADVS AU - Rao,Rajini TI - Organellar calcium pumps of the golgi and ER: from yeast to human T2 - Calcium signaling I : regulation, mechanisms, effectors, role in disease and recent advances, PY - 2007/// CY - London PB - Henry Stewart Talks KW - Calcium Signaling KW - Golgi Apparatus N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Early and current views on Calcium signaling -- Phylogenetic tree of Calcium-ATPases -- Identification of a new family of Golgi/secretory pathway Calcium-ATPases (SPCA) -- Why have a Calcium pump in the Golgi? -- Yeast as a model to understand Golgi Calcium pumps -- Biochemical characterization of Calcium and Mn2+ transport -- Phenotype screening in yeast to identify residues important for ion transport and selectivity in Pmr1 -- Structural and homology models of Calcium-ATPases -- Golgi pumps in mammals -- From structure to physiology -- Haploinsufficiency of ATP2C1 leads to Hailey Hailey disease -- Insights from yeast -- Distribution and localization of SPCA1 and SPCA2; Access restricted to subscribers UR - https://hstalks.com/bs/413/ UR - https://hstalks.com/bs/p/13/ ER -