TY - ADVS AU - Kraft,Peter AU - Spiegelman,Donna TI - Statistical issues in epidemiologic studies of gene-environment interaction T2 - Gene-environment interactions : role in the modulation of pulmonary and autoimmune disease risks, PY - 2007/// CY - London PB - Henry Stewart Talks KW - Environmental Exposure KW - Genes KW - Genetic Predisposition to Disease KW - Models, Statistical KW - Risk Factors N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Gene-environment interaction in the development of human traits, including disease -- Conceptual and analytical challenges -- Joint analysis of data on both genetic and environmental factors from epidemiologic studies as a way to increase power to detect a polymorphism (or an exposure) that is associated with disease risk -- Study designs -- Statistical modeling issues in the analysis of data -- Sample size and power calculations for a range of designs -- Specification of parameters -- Ordinal coding -- Hierarchical models -- The analysis of highdimensional "pathway" data (multiple related genes and environmental exposures); Access restricted to subscribers UR - https://hstalks.com/bs/79/ UR - https://hstalks.com/bs/p/24/ ER -