TY - ADVS AU - Levin,Michael TI - Left-right asymmetry in embryonic development: how epigenetic, biophysical forces and gene activity interplay to determine a major embryonic axis T2 - The biomedical & life sciences collection, PY - 2011/// CY - London PB - Henry Stewart Talks KW - Developmental genetics KW - Embryology KW - Body Patterning KW - Embryonic Development KW - Gene Expression Regulation, Developmental KW - Ion Transport N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Types of symmetry in animal bodyplans -- Left-right asymmetry definition -- Human laterality -- facts about normal human asymmetry -- Ways asymmetry can go wrong -- Clinical applications of left-right asymmetry -- Left-right pathway -- Asymmetric gene expression -- Loss-of-function pharmacological screen -- Ion transporters in left-right patterning -- Novel localization mechanisms -- Molecular loss-of-function experiments -- Gain-of-function experiments -- Expression and function of the ion flux system -- Serotonin: a neurotransmitter with many roles -- Serotonin and asymmetry -- Phases during left-right patterning -- The relationship between physiological signals and the ciliary model of LR asymmetry -- Is nodal flow required for consistent asymmetry? -- 3 fundamental models of LR asymmetry; Access restricted to subscribers UR - https://hstalks.com/bs/1947/ ER -