TY  - ADVS
AU  - Neyts,Johan
TI  - Towards the development of potent therapy against the Hepatitis C virus
T2  - Antivirals : latest developments and future progress,
PY  - 2011///
CY  - London
PB  - Henry Stewart Talks
KW  - Antiviral agents
KW  - Hepatitis C virus
KW  - Hepatitis C
KW  - Treatment
KW  - Antiviral Agents
KW  - Hepacivirus.
KW  - drug therapy
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: The HCV genome and replication cycle -- Interferon development -- Ribavirin -- Antiviral and GTP depletion correlation -- Selective inhibitors of HCV replication -- The NS2 cysteine and the NS3 serine proteases -- Protease inhibitors -- The NS3 helicase as an antiviral target -- NS4A/NS3, NS4B and NS5A as antiviral targets -- The NS5B RNA dependent RNA polymerase -- Nucleoside and non-nucleoside HCV inhibitors -- Double and triple combination therapies -- Debio-025 -- Resistance to HCV inhibitors -- D320E peptide mutation effect -- Role of NS5A or NS5B in resistance -- Wild type and CypA knock down studies -- Cis-trans isomerase activity of cyclophilins; Access restricted to subscribers
UR  - https://hstalks.com/bs/2072/
UR  - https://hstalks.com/bs/p/613/
ER  -