TY - ADVS AU - Michaelson,Daniel TI - ApoE4, the most prevalent genetic risk factor for Alzheimer's Disease T2 - Alzheimer's disease : neurobiology, pathology and treatment, PY - 2012/// CY - London PB - Henry Stewart Talks KW - Alzheimer's disease KW - Genetic aspects KW - Pathology KW - Alzheimer Disease KW - genetics KW - pathology KW - Apolipoprotein E4 KW - Risk Factors N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: ApoE4 the most prevalent genetic risk factor of Alzheimer's disease -- The apoE4 molecule -- The associated brain pathology in man -- The mechanisms underlying the pathological effects of apoE4 -- The role of lipids in mediating the effects of apoE4 -- The role of Amyloid-beta in mediating the effects of apoE4 -- ApoE4 receptors -- ApoE4 catabolism -- ApoE4 targeted therapeutic approaches -- Therapeutic approaches based on the apoE4 molecule -- Therapeutic approaches based on preventing pathologic interactions with other systems; Access restricted to subscribers UR - https://hstalks.com/bs/2402/ UR - https://hstalks.com/bs/p/529/ ER -