TY  - ADVS
AU  - Klitgaard,Henrik
TI  - Discovery of Levetiracetam (Keppra(R)): the first SV2A ligand for the treatment of epilepsy 
T2  - Drug discovery and development in the neurosciences,
PY  - 2013///
CY  - London
PB  - Henry Stewart Talks
KW  - Anticonvulsants
KW  - Convulsions
KW  - Chemotherapy
KW  - Drug development
KW  - Epilepsy
KW  - pharmacology
KW  - therapeutic use
KW  - Drug Discovery
KW  - drug therapy
KW  - Molecular Targeted Therapy
KW  - Piracetam
KW  - Seizures
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Levetiracetam -- Antiepileptic Drug Discovery -- Levetiracetam in electroshock and PTZ seizures -- Protection against seizures in rat model -- Levetiracetam activity in GAERS model -- Impact on cognitive function -- Hyper-synchronization / excitability inhibition in vitro -- Effect on development of amygdala kindling -- Effect on seizures in genetic models of epilepsy -- Inactivation of sodium channels -- Reduction of current through T-type Ca channels -- Levetiracetam mechanism of action -- SV2 proteins: candidates for the LEV binding site -- SV2A cloning and binding studies -- Levetiracetam studies in SV2A (+/-) mice -- Profile of new class of antiepileptic drugs; Access restricted to subscribers
UR  - https://hstalks.com/bs/2524/
UR  - https://hstalks.com/bs/p/684/
UR  - https://hstalks.com/bs/p/739/
ER  -