TY  - ADVS
AU  - Saunders,Norman
TI  - Barrier mechanisms in the developing brain: protection or vulnerability? 
T2  - The blood-brain barrier : understanding the regulatory gatekeeper between brain and body,
PY  - 2014///
CY  - London
PB  - Henry Stewart Talks
KW  - Biological transport
KW  - Blood-brain barrier
KW  - Brain
KW  - Growth
KW  - Blood-Brain Barrier
KW  - cytology
KW  - embryology
KW  - growth & development
KW  - metabolism
KW  - Capillary Permeability
KW  - Carrier Proteins
KW  - Intercellular Junctions
KW  - Maternal Exposure
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: The brain develops within a well-defined internal environment -- The properties of this internal environment are determined by transporters in the cellular interfaces between the blood, brain and cerebrospinal fluid -- The transporters are effective because the intercellular spaces between the cells in the interfaces are sealed by tight junctions -- The transporters are both influx and efflux and many are active very early in brain development -- Although brain barrier mechanisms are present very early in development they are vulnerable to pathological conditions e.g. inflammation, which may result in barrier dysfunction and damage to the fragile developing brain -- These mechanisms thus provide protection and a stable internal environment, but some may render the developing brain more vulnerable e. g. inward transport of toxins such as mercury via a normal amino acid transporter; Access restricted to subscribers
UR  - https://hstalks.com/bs/2721/
UR  - https://hstalks.com/bs/p/277/
ER  -