TY - ADVS AU - Swerdlow,Daniel I. AU - Holmes,Michael V. TI - Key drug discovery challenges in cardiovascular medicine T2 - Genetics of cardiovascular disease : genetic interactions in a multifactorial disease, PY - 2014/// CY - London PB - Henry Stewart Talks KW - Cardiovascular agents KW - Cardiovascular system KW - Diseases KW - Chemotherapy. KW - Drug development KW - Drugs KW - Research KW - Pharmacogenetics KW - Cardiovascular Agents KW - therapeutic use KW - Cardiovascular Diseases KW - drug therapy KW - Drug Discovery KW - methods KW - Precision Medicine N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Conventional therapeutic targets in CVD -- Identifying new targets (GWAS and association analysis) -- Validating new targets (Mendelian randomisation; IL6R, CHD and tocilizumab; sPLA2 inhibition and CHD prevention) -- Avoiding adverse effects (The ILLUMINATE trial, Torcetrapib and blood pressure) -- Making better use of existing drugs (Pharmacogenetics of Clopidogrel and CYP2C19) -- New approaches & drug development; Access restricted to subscribers UR - https://hstalks.com/bs/2770/ UR - https://hstalks.com/bs/p/379/ UR - https://hstalks.com/bs/p/739/ ER -