TY  - ADVS
AU  - Dickenson,A.H.
TI  - Receptors and channels in pain
T2  - Synapses, neurotransmitters and receptor channels,
PY  - 2014///
CY  - London
PB  - Henry Stewart Talks
KW  - Analgesia
KW  - Central nervous system
KW  - Physiology
KW  - Ion channels
KW  - Nociceptors
KW  - Pain
KW  - Synapses
KW  - Analgesics
KW  - pharmacology
KW  - therapeutic use
KW  - Central Nervous System
KW  - physiology
KW  - Ion Channels
KW  - drug effects
KW  - physiopathlogy
KW  - drug therapy
KW  - physiopathology
KW  - Receptors, Neurotransmitter
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: CNS pain circuits -- Receptors, ligands , mediators & ion channels involved in pain signaling -- Key types of pain -- Inflammation (ongoing activation of pain sensors) -- Nerve growth factor and bone innervation -- Tanezumab: humanized monoclonal antibody -- Symptoms of neuropathic pain -- Sodium channel changes, redistribution, activation -- Channelopathic pain syndromes -- Pregabalin and gabapentin -- Ca channels -- Peripheral activity causes central hyperexcitability -- Post-synaptic neuron activation -- Spinal mechanisms -- NMDA receptors -- Central sensitization -- Noradrenaline and 5HT -- Pain sensitivity: pathway alterations -- Reduced NA\increased 5HT function: effects -- Diffuse Noxious Inhibitory Controls (DNIC) -- Morphine and codeine -- Opioid mechanisms -- Pain signaling, multi-level changes & drug targets -- Similar symptoms\signs: many mechanisms; Access restricted to subscribers
UR  - https://hstalks.com/bs/2779/
UR  - https://hstalks.com/bs/p/798/
ER  -