TY - ADVS AU - Boeree,Martin TI - Management of MDR and XDR TB T2 - Respiratory infection, PY - 2014/// CY - London PB - Henry Stewart Talks KW - Antitubercular agents KW - International cooperation KW - Multidrug-resistant tuberculosis KW - Tuberculosis KW - Chemotherapy KW - Prevention KW - Antitubercular Agents KW - pharmacology KW - Extensively Drug-Resistant Tuberculosis KW - drug therapy KW - prevention & control KW - International Cooperation KW - history KW - Tuberculosis, Multidrug-Resistant N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Management of multi drug resistance (MDR) and extensive drug resistance (XDR) TB -- Management of TB before era of drug treatment -- Surgery for TB -- Drug treatment was introduced from 1943-1963 -- Rifampicin (1963) -- Timeline: discovery of drugs for TB -- Emergence of totally drug resistant TB -- Epidemiology -- Outcomes of MDR-TB treatment -- Survival curve of HIV patients with XDR TB -- Current drug treatment -- Treatment outcome in several cohorts -- Death rates in several cohorts -- Current approach for treatment of MDR/XDR TB -- WHO's programmatic management of DR TB -- Treatment recommendations -- Group 1: oral first-line agents -- Group 2: fluoroquinolones -- Group 3: injectables -- Group 4: less-effective anti-TB drugs -- Group 5: less-effective or clinical data sparse drugs -- Future drug treatment -- New compounds -- Bedaquiline (TMC207) -- The nitroimidazoles -- Thioridazine -- NC-001 (PA-824, moxifloxacine, PZA) -- Dreams and realities for the future of TB treatment; Access restricted to subscribers UR - https://hstalks.com/bs/2809/ UR - https://hstalks.com/bs/p/726/ ER -