TY - ADVS AU - Schaffer,David V. TI - Directed evolution of novel adeno-associated viral vectors for gene therapy T2 - Gene transfer and gene therapy, PY - 2014/// CY - London PB - Henry Stewart Talks KW - Adenoviruses KW - Gene therapy KW - Genetic transformation KW - Genetic vectors KW - Therapeutic use KW - Retina KW - Diseases KW - Treatment KW - Viral genetics KW - Adenoviridae KW - genetics KW - Dependovirus KW - Gene Transfer Techniques KW - Genetic Therapy KW - methods KW - trends KW - Genetic Vectors KW - therapeutic use KW - Retinal Diseases KW - therapy N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Recent successes in gene therapy -- Problems in the field with naturally derived vectors -- Directed evolution as an approach to engineer optimal viral vector variants that meet clinical needs -- Examples: development of variants to evade neutralizing antibodies and evolution for enhanced delivery in the retina; Access restricted to subscribers UR - https://hstalks.com/bs/2875/ UR - https://hstalks.com/bs/p/808/ ER -