TY - ADVS AU - Ivics,Zoltan TI - Turning genomic junk into treasure: genetic engineering with the Sleeping Beauty transposon system T2 - Gene transfer and gene therapy, PY - 2014/// CY - London PB - Henry Stewart Talks KW - Gene therapy KW - Genetic engineering KW - Genetic transformation KW - Genetic vectors KW - Therapeutic use KW - DNA Transposable Elements KW - Gene Knock-In Techniques KW - Gene Therapy KW - methods KW - Gene Transfer Techniques KW - Genetic Engineering KW - Genetic Vectors KW - therapeutic use KW - Genomics KW - Transformation, Genetic KW - Transposases KW - metabolism N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Transposons can be viewed as natural DNA transfer vehicles -- Transposons are capable of efficient genomic insertion, similar to integrating viruses -- Transposition can be controlled by conditionally providing the transposase enzyme -- DNA of interest cloned into a transposon-based vector can be utilized for stable genomic insertion in a regulated and highly efficient manner -- Transposition opens up many avenues for genome manipulations in vertebrates -- Generation of transgenic cells and germline-transgenic animals using transposons -- The Sleeping Beauty synthetic transposon -- Clinical applications of the Sleeping Beauty system; Access restricted to subscribers UR - https://hstalks.com/bs/2876/ UR - https://hstalks.com/bs/p/808/ ER -