TY  - ADVS
AU  - Alon,Uri
TI  - Evolutionary tradeoffs and the geometry of gene expression space
T2  - Systems biology,
PY  - 2014///
CY  - London
PB  - Henry Stewart Talks
KW  - Bioinformatics
KW  - Biological models
KW  - Evolution (Biology)
KW  - Gene expression
KW  - Mathematical optimization
KW  - Molecular biology
KW  - Morphology (Animals)
KW  - Phenotype
KW  - Beak
KW  - anatomy & histology
KW  - Biological Evolution
KW  - Computational Biology
KW  - Evolution, Molecular
KW  - Fossils
KW  - Gene Expression
KW  - Genes, Bacterial
KW  - Genetic Fitness
KW  - Models, Biological
KW  - Models, Statistical
KW  - Selection, Genetic
KW  - Systems Biology
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Organisms, tissues and molecules often need to perform multiple tasks -- Usually no phenotype can be optimal at all tasks at once which leads to a fundamental tradeoff -- We study this using the concept of Pareto optimality from engineering and economics -- Tradeoffs lead to an unexpected simplicity in the range of optimal phenotypes; they fall on low dimensional shapes in trait space such as lines, triangles and tetrahedrons -- At the vertices of these polygons are phenotypes that specialize at a single task -- We demonstrate this using data from animal and fossil morphology, bacterial gene expression and other biological systems; Access restricted to subscribers
UR  - https://hstalks.com/bs/2938/
UR  - https://hstalks.com/bs/p/876/
ER  -