TY  - ADVS
AU  - Zhang,Rumin
TI  - Quantitative analysis of receptor allosterism and its implication for drug discovery
T2  - The biomedical & life sciences collection,
PY  - 2015///
CY  - London
PB  - Henry Stewart Talks
KW  - Cell receptors
KW  - Drug development
KW  - Drug receptors
KW  - Pharmaceutical chemistry
KW  - Drug Agonism
KW  - Drug Discovery
KW  - Receptors, Cytoplasmic and Nuclear
KW  - Receptors, G-Protein-Coupled
KW  - agonists
KW  - chemistry
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: G protein-coupled receptors (GPCRs) -- Receptor agonism and allosterism --  Orthosteric and allosteric binders -- Inverse, partial and full agonists -- Positive, silent and negative allosteric modulators (PAMs, SAMs and NAMs) -- Allosteric two-state model and general operational model with constitutive receptor activity -- Optimal design of experiment -- Global curve fitting analysis of affinity and efficacy parameters -- Beta supremacy -- Monte Carlo simulations; Access restricted to subscribers
UR  - https://hstalks.com/bs/3187/
ER  -