TY - ADVS AU - Dudbridge,Frank TI - Winner's curse, replication and meta-analysis T2 - Statistical genetics, PY - 2016/// CY - London PB - Henry Stewart Talks KW - Gene mapping KW - Statistical methods KW - Genetics KW - Biometry KW - Chromosome Mapping KW - methods KW - Computational Biology KW - Data Interpretation, Statistical KW - statistics & numerical data KW - Genome-Wide Association Study KW - Models, Statistical KW - Statistics as Topic N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Winner's curse: tendency to see a larger effect than usual upon discovery -- Examples from GWAS -- Methods for obtaining unbiased estimates -- Replication: confirming genetic associations in further studies -- Technical, direct and indirect replication -- Meta-analysis: combining multiple GWAS -- Forest plots, fixed and random effects, sources of heterogeneity in GWAS; Access restricted to subscribers UR - https://hstalks.com/bs/3254/ UR - https://hstalks.com/bs/p/963/ ER -