TY - ADVS AU - Pyle,Anna Marie TI - Self-splicing intron RNAs: ribozymes, parasites and agents of genomic change T2 - From DNA to proteins : the multiple levels of regulation, PY - 2007/// CY - London PB - Henry Stewart Talks KW - Introns KW - Protein-protein interactions KW - RNA splicing KW - Evolution, Molecular KW - genetics KW - physiology KW - RNA Splicing KW - RNA KW - chemistry KW - metabolism KW - RNA, Catalytic KW - Spliceosomes N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Different classes of introns -- Autocatalytic group I and group II introns -- Discovery of self-splicing -- Converting a self-splicing RNA into a multiple-turnover enzyme -- The "tetrahymena ribozyme" and discovery of RNA catalysis -- New insights into molecular recognition of RNA -- Group I intron structure and catalytic mechanism -- Group I intron applications -- Group II introns and the big picture -- Discovery of self-splicing by group II introns -- Chemical mechanism of group II intron reactions -- Catalytic engines for driving eukaryotic evolution -- Explaining specificity of group II ribozymes -- Group II intron ribozymes as model systems for RNA folding -- Group II ribozymes as model systems for RNA tertiary structure -- Nucleotide analog interference mapping -- Current map of important atoms -- Nucleotide analog interference suppression -- Lambda-lambda interaction -- 3D model of ai5gamma intron -- Group II introns as tools and therapeutics; Access restricted to subscribers UR - https://hstalks.com/bs/626/ UR - https://hstalks.com/bs/p/22/ ER -