TY - ADVS AU - Luzzatto,Lucio TI - Complement in PNH and other hemolytic anaemias: part 3 of 3 T2 - The complement system, PY - 2017/// CY - London PB - Henry Stewart Talks KW - Complement (Immunology) KW - Hemolytic anemia KW - Immunologic diseases KW - Paroxysmal hemoglobinuria KW - Anemia, Hemolytic KW - Antibodies, Monoclonal, Humanized KW - Bone Marrow KW - Complement Activation KW - drug effects KW - Complement System Proteins KW - eculizumab KW - Erythrocytes KW - Hemoglobinuria, Paroxysmal KW - drug therapy KW - pathology KW - Hemolysis KW - Iatrogenic Disease N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Complement-targeted therapy for PNH -- Mechanism of (iatrogenic) hemolysis in PNH -- Pathogenesis of PNH -- Anaemias due to intravascular hemolysis -- Bone marrow failure and PNH -- Somatic mutations in PNH -- Clinical burden of PNH -- PNH: issues in management -- Eculizumab (anti-C5 Ab): targeted therapy for PNH; Access restricted to subscribers UR - https://hstalks.com/bs/3542/ UR - https://hstalks.com/bs/p/1036/ ER -