TY - ADVS AU - Benkovic,Stephen J. TI - Perspectives on biological catalysis T2 - Chemical biology : the role of chemistry in our fundamental understanding of biology, PY - 2017/// CY - London PB - Henry Stewart Talks KW - Catalysis KW - Enzymes KW - chemistry KW - Kinetics KW - Models, Chemical KW - Protein Conformation KW - Tetrahydrofolate Dehydrogenase N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Updated version of a talk first published in 2007; Contents: How do enzyme motions and fluctuations impact catalysis? -- Are the times scales for protein structural changes and the enzymatic catalytic cycle similar? -- How are electrostatics modulated in enzyme active sites in conjunction with catalysis? -- Dihydrofolate reductase as a model: kinetics, reactions & structure; Access restricted to subscribers UR - https://hstalks.com/bs/43/ UR - https://hstalks.com/bs/p/279/ UR - https://hstalks.com/bs/p/33/ ER -