TY - ADVS AU - Beedham,Christine TI - Non-P450 oxidative metabolism: characteristics and drug substrates T2 - Drug metabolizing enzymes : fundamentals, study methods, recent advances and clinical significance, PY - 2019/// CY - London PB - Henry Stewart Talks KW - Drugs KW - Metabolism KW - Enzymes KW - Oxidation-reduction reaction KW - Oxidoreductases KW - Alcohol Dehydrogenase KW - Aldehyde Dehydrogenase KW - Aldehyde Oxidase KW - Cytochromes KW - Isoenzymes KW - Monoamine Oxidase KW - Monooxygenases KW - Oxidation Reduction KW - metabolism KW - Pharmaceutical Preparations KW - Reactive Oxygen Species KW - Substrate Specificity KW - Xanthine Dehydrogenase KW - Xanthine Oxidase KW - Xenobiotics N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Updated version of a talk first published in 2007; Contents: Non-P450 cytosolic and mitochondrial enzymes catalysing drug oxidation -- Aldehyde oxidase and xanthine oxidase -- Alcohol dehydrogenase and aldehyde dehydrogenase -- Monoamine oxidase -- Flavin monooxygenase -- Substrate specificities -- Drug and xenobiotic substrates -- Catalytic mechanism and metabolite formation -- Reactive oxygen species -- Factors affecting enzyme activity -- Polymorphism and isozymes -- Relative importance in drug metabolism; Access restricted to subscribers UR - https://hstalks.com/bs/688/ UR - https://hstalks.com/bs/p/16/ ER -