TY - ADVS AU - Grisshammer,R.K. TI - Structural and mechanistic insights into the neurotensin receptor T2 - G Protein-Coupled Receptors (GPCRs) signaling in health and disease, PY - 2019/// CY - London PB - Henry Stewart Talks KW - Cellular signal transduction KW - G proteins KW - Receptors KW - Molecular structure KW - Neurotensin KW - Molecular Dynamics Simulation KW - chemistry KW - metabolism KW - Protein Conformation KW - Receptors, G-Protein-Coupled KW - Receptors, Neurotensin N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: G protein-coupled receptors -- Neurotensin receptor -- Peptide agonist neurotensin tools for crystallization of membrane proteins -- Conformational thermostabilization -- Crystal structure of NTSR1-GW5 -- Binding mode of neurotensin -- Crystal structures of NTSR1-ELF & NTSR1-LF-prerequisites for G protein activation -- Crystal structure of NTSR1-EL -- Constitutive activity -- Molecular dynamics simulations; Access restricted to subscribers UR - https://hstalks.com/bs/3998/ UR - https://hstalks.com/bs/p/1083/ ER -