TY  - ADVS
AU  - Rubinsztein,D.C.
TI  - The molecular biology of Huntington's disease
T2  - Neurodegenerative diseases : fundamentals, research methods, latest advances,
PY  - 2020///
CY  - London
PB  - Henry Stewart Talks
KW  - Huntington's disease
KW  - HTT protein, human
KW  - Huntingtin Protein
KW  - Huntington Disease
KW  - genetics
KW  - pathology
KW  - therapy
KW  - Molecular Biology
KW  - Neurodegenerative Diseases
KW  - Protein Aggregates
KW  - Reactive Oxygen Species
KW  - RNA, Small Interfering
KW  - Trinucleotide Repeat Expansion
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Updated version of a talk first published in 2007; Contents: Clinical presentations of HD -- Pathological features -- Genetic basis -- Trinucleotide repeat expansion mutation -- Huntingtin protein and cell damage -- Abnormal protein aggregation -- Transcriptional abnormalities -- Raised levels of reactive oxygen species -- Future directions for therapeutic intervention -- siRNA approaches -- Induction of autophagy; Access restricted to subscribers
UR  - https://hstalks.com/bs/230/
UR  - https://hstalks.com/bs/p/31/
ER  -