TY - ADVS AU - Philpott,Dana TI - Microbial recognition and the immune response T2 - Molecular basis of bacterial infection : virulence factors of pathogenic bacteria and how they work, PY - 2020/// CY - London PB - Henry Stewart Talks KW - Bacterial diseases KW - Immunological aspects KW - Immune system KW - Adaptive Immunity KW - Antibody Formation KW - Bacterial Infections KW - immunology KW - Disease Resistance KW - Immunity, Innate KW - Inflammasomes KW - NF-kappa B KW - Nod1 Signaling Adaptor Protein KW - Nod2 Signaling Adaptor Protein KW - Shigella flexneri KW - Signal Transduction KW - Toll-Like Receptors KW - Virulence Factors N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Updated version of a talk first published in 2009; Contents: How can our cells tell that something is foreign? -- Overview of innate immunity -- Cell signaling PRMs -- Toll-like receptors -- Shigella flexneri -- NLRs are related to plant R proteins involved in disease resistance -- NLRs: detectors of MAMPs and danger signals -- Proposed mechanism for Nod protein activation by a MAMP -- Alerting the cell: Nod1 activates NFkB -- Critical role of Nod1 in infected intestinal epithelial cells -- Proposed mechanism for NLRP protein activation by a DAMP -- The inflammasomes -- How do innate immune signals translate into adaptive immune responses? -- Implication of Nod1 and Nod2 in adaptive immune responses -- TLRs vs. Nods -- Nod1 is required for priming adaptive immunity -- What is the compartment that carries Nod1-specific function?; Access restricted to subscribers UR - https://hstalks.com/bs/1481/ UR - https://hstalks.com/bs/p/1067/ UR - https://hstalks.com/bs/p/441/ ER -