TY - ADVS AU - Carrington,Mary TI - The influence of variation at the killer cell immunoglobulin-like receptor gene complex on human disease T2 - Natural killer cell biology : natural killer cell-mediated immunity to pathogens and cancer, PY - 2021/// CY - London PB - Henry Stewart Talks KW - Immunogenetics KW - Killer cells KW - Acquired Immunodeficiency Syndrome KW - immunology KW - Arthritis, Psoriatic KW - Autoimmune Diseases KW - genetics KW - Genetic Variation KW - Hepatitis C KW - HIV Infections KW - Infections KW - Killer Cells, Natural KW - Ligands KW - Maternal-Fetal Exchange KW - Multigene Family KW - Neoplasms KW - Pregnancy KW - Receptors, Immunologic KW - metabolism KW - Receptors, KIR N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Updated version of a talk first published in 2009; Contents: Domain structure of human KIRs -- HLA class I and KIR -- Stochastic expression of KIR genes -- HLA ligands for KIRs -- KIR polymorphism -- KIR disease associations: autoimmune, maternal-fetal, cancer and infectious -- NK cell activation probably enhances HCV clearance -- NK cell activation probably protects against persistent HCV infection, reproductive failure and early after HIV infection AIDS progression -- NK cell inhibition probably protects against psoriatic arthritis and cervical neoplasia -- Striking a balance between activating and inhibitory KIR genotypes; Access restricted to subscribers UR - https://hstalks.com/bs/1460/ UR - https://hstalks.com/bs/p/440/ ER -