TY  - ADVS
AU  - Stark,Mike
AU  - Tanaka,Tomo
TI  - Chromosome bi-orientation in yeast
T2  - The cell division cycle : controlling when and where cells divide and differentiate,
PY  - 2022///
CY  - London
PB  - Henry Stewart Talks
KW  - Saccharomyces cerevisiae
KW  - Genetics
KW  - Yeast fungi
KW  - Aneuploidy
KW  - Aurora Kinases
KW  - Cell Cycle
KW  - Chromatids
KW  - Chromosomes, Fungal
KW  - Kinetochores
KW  - Microtubules
KW  - genetics
KW  - physiology
KW  - Spindle Apparatus
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Updated version of a talk first published in 2009; Contents: What is chromosome biorientation and why is it important? -- Failure to bi-orient a chromosome will lead to mis-segregation/aneuploidy -- Modes of sister chromatid attachment to spindle microtubules -- The budding yeast (Saccharomyces cerevisiae) as a model for studying chromosome bi-orientation -- Monitoring sister centromeres on individual yeast chromosomes -- Kinetochore capture -- Achieving chromosome bi-orientation: mechanisms -- Geometry-dependent mechanism or a correction mechanism? -- Yeast Ipl1p kinase -- Chromosomes fail to bi-orient with high frequency in Ipl1 mutants -- How might Ipl1p kinase promote bi-orientation? -- Yeast chromosomes can bi-orient without the need for back-to-back geometry -- How does Ipl1p kinase promote bi-orientation? -- The yeast chromosomal passenger complex -- Models for tension-sensing -- What are the targets of Ipl1p kinase at the kinetochore? -- Model for Ipl1 / Aurora function in promoting bi-orientation -- Does Aurora B have similar targets in other organisms? -- Other components required for bi-orientation -- Ipl1p kinase may coordinate chromosome bi-orientation and spindle checkpoint activation; Access restricted to subscribers
UR  - https://hstalks.com/bs/1262/
UR  - https://hstalks.com/bs/p/381/
ER  -