TY  - ADVS
AU  - Lopez,Angel
AU  - Hercus,Timothy
TI  - The b common (bc) family of cytokines, receptors and ligands
T2  - Cytokines : intercellular mediators regulating host defense,
PY  - 2022///
CY  - London
PB  - Henry Stewart Talks
KW  - Autoimmunity
KW  - physiology
KW  - Cytokines
KW  - Physiology
KW  - Receptors
KW  - Ligands (Biochemistry)
KW  - Granulocyte-Macrophage Colony-Stimulating Factor
KW  - Inflammation
KW  - physiopathology
KW  - Interleukins
KW  - Ligands
KW  - Receptors, Cytokine
KW  - Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
KW  - Signal Transduction
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Updated version of a talk first published in 2011; Contents: Beta common cytokines -- Excessive beta common cytokine function results in inflammatory diseases -- Function through heterodimeric receptors -- The alpha subunits have a conserved architecture -- The beta subunit -- Formation of a soluble GM-CSF receptor complex -- Key interaction between cytokine and beta common, Site 2 -- Structure of soluble GM-CSF receptor complex -- Crystal structure revealed a higher-order complex -- Key dodecamer interactions are essential for receptor signalling -- Knowledge of receptor activation mechanism contributes to inhibitor development; Access restricted to subscribers
UR  - https://hstalks.com/bs/2149/
UR  - https://hstalks.com/bs/p/611/
ER  -