TY - BOOK AU - Blossey,Ralf TI - Computational biology: a statistical mechanics perspective T2 - Chapman & Hall/CRC mathematical and computational biology SN - 9780429503672 AV - QH506 .B57 2020eb U1 - 572.80285 23 PY - 2020///] CY - Boca Raton, Florida PB - CRC Press KW - Biomolecules KW - Mechanical properties KW - Statistical mechanics KW - Computational biology KW - SCIENCE / Life Sciences / Biochemistry KW - bisacsh KW - COMPUTERS / General KW - COMPUTERS / Computer Graphics / Game Programming & Design KW - SCIENCE / Life Sciences / Biology / General N1 - Part 1: Equilibrium statistical mechanics -- Equilbrim statistical mechanics -- Biomolecular structure: DNA, RNA, proteins -- Phase transitions in RNA -- Soft matter electrostatics -- Part 2: Non-equilibrium statistical mechanics -- Back to P: probabilities over time -- Fluctuation theorems -- Dynamics of biological networks -- Biological networks: space N2 - Computational biology has developed rapidly during the last two decades following the genomic revolution which culminated in the sequencing of the human genome. More than ever it has developed into a field which embraces computational methods from different branches of the exact sciences: pure and applied mathematics, computer science, theoretical physics. This Second Edition provides a solid introduction to the techniques of statistical mechanics for graduate students and researchers in computational biology and biophysics. Material has been reorganized to clarify equilbrium and nonequilibrium aspects of biomolecular systems Content has been expanded, in particular in the treatment of the electrostatic interactions of biomolecules and the application of non-equilibrium statistical mechanics to biomolecules New network-based approaches for the study of proteins are presented. All treated topics are put firmly in the context of the current research literature, allowing the reader to easily follow an individual path into a specific research field. Exercises and Tasks accompany the presentations of the topics with the intention of enabling the readers to test their comprehension of the developed basic concepts UR - https://www.taylorfrancis.com/books/9780429503672 UR - http://www.oclc.org/content/dam/oclc/forms/terms/vbrl-201703.pdf ER -