TY  - ADVS
AU  - Hardwick,Kevin G.
TI  - The spindle checkpoint
T2  - The cell division cycle : controlling when and where cells divide and differentiate,
PY  - 2009///
CY  - London
PB  - Henry Stewart Talks
KW  - Cell Cycle
KW  - Mitosis
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Cell cycle checkpoints -- The metaphase to anaphase transition -- The spindle checkpoint -- What do cells monitor? -- Unattached kinetochores -- Lack of tension -- Checkpoint components -- Budding yeast genetic screens -- Microcolony assay -- Localisation of Mad proteins -- Checkpoint proteins are all recruited kinetochores -- Role of kinetochores -- Global signaling -- Identification of Cdc20 as the checkpoint effector -- CdC20-APC -- FRAP -- Mad1/Mad2 complex as a template -- The anaphase promoting complex (APC) -- How is anaphase onset inhibited -- Mad2 and Mad3 bind mitotic APC -- Separase regulation by securin -- Error correction -- Chromosomal passenger proteins -- How to sense a lack of tension? -- Checkpoint role(s) of Aurora kinase (Ipl1) -- Checkpoint silencing -- Disease relevance -- Future directions; Access restricted to subscribers
UR  - https://hstalks.com/bs/1266/
UR  - https://hstalks.com/bs/p/381/
ER  -