TY  - ADVS
AU  - Murray,Peter J.
TI  - Arginase and nitric oxide
T2  - Innate immunity : host recognition and response in health and disease,
PY  - 2011///
CY  - London
PB  - Henry Stewart Talks
KW  - Arginase
KW  - Natural immunity
KW  - Nitric oxide
KW  - arginase I, human
KW  - Arginine
KW  - Immunity, Innate
KW  - Macrophages
KW  - Nitric Oxide Synthase Type II
KW  - Nitric Oxide
KW  - NOS2 protein, human
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Updated version of a talk first published in 2009; Contents: Catabolism of arginine to downstream substrates -- Catabolism of arginine in macrophages -- Nitric oxide production -- Control of iNOS at the transcriptional level -- Role of nitric oxide in immunity to intracellular pathogens with a focus on mycobacterial disease -- Structure of arginases -- Transcriptional control of arginase 1 in the liver vs. macrophages -- Arginases can suppress nitric oxide production by substrate depletion -- Pathogens use many mechanisms to regulate nitric oxide -- Arginases and alternatively-activated macrophages (AAMs) -- Schistosome infection as an example of AAM function -- AAMs and arginases -- Arginase inhibition by small molecules -- Outstanding questions; Access restricted to subscribers
UR  - https://hstalks.com/bs/1301/
UR  - https://hstalks.com/bs/p/437/
ER  -