TY - ADVS AU - Kovanen,Petri TI - Rupture of an atherosclerotic plaque: a consequence of cholesterol accumulation and inflammation in the arterial intima T2 - Genetics of cardiovascular disease : genetic interactions in a multifactorial disease, PY - 2008/// CY - London PB - Henry Stewart Talks KW - Atherosclerosis KW - physiopathology KW - Cardiovascular Diseases KW - genetics KW - Cholesterol KW - Tunica Intima N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Inflammation and aetherosclerosis -- Immune activation -- Response to injury hypothesis -- Discovery of the pathophysiology of aetherosclerosis -- The cholesterol era -- The LDL level -- Arterial intima: the site of atherogenesis -- Genesis of thickening intima -- Adaptive intimal thickening -- Topology of coronary athero-sclerotic lesions -- Cholesterol in blood and in coronary arterial wall -- The "bad" LDL cholesterol and the "good" HDL cholesterol: an imbalance -- Coronary artery disease -- LDL-driven atherosclerosis leads to coronary stenosis -- Human coronary atheroma -- Atherothrombosis -- Plaque disruption -- Structure of an LDL particle -- Extracellular aggregated and fused LDL particles in the arterial intima of genetically hyperlipidemic mouse -- Extracellular lipid droplets in human atherosclerotic plaque -- Fatty streak formation in human fetal aortas is enchanced by maternal hypercholesterolemia; Access restricted to subscribers UR - https://hstalks.com/bs/1053/ UR - https://hstalks.com/bs/p/379/ ER -