TY - ADVS AU - Pan,D.J. TI - Control of tissue growth: elucidation of the Hippo signaling pathway T2 - The legacy of Drosophila genetics : from 'defining the gene' to 'analyzing genome function', PY - 2008/// CY - London PB - Henry Stewart Talks KW - Drosophila KW - genetics N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Genetic screens for tumor suppressors in Drosophila -- Identification of the Warts tumor suppressor -- Identification of Hippo tumor suppressor and elucidation of the Hippo kinase cascade -- Discovery of Yorkie as the nuclear effector of the Hippo pathway -- Mechanism of Yorkie inactivation by phosphorylation -- Conservation of the Hippo kinase cascade in mammals -- The role of the Hippo pathway in mammalian organ size control and tumorigenesis; Access restricted to subscribers UR - https://hstalks.com/bs/990/ UR - https://hstalks.com/bs/p/283/ ER -