TY  - ADVS
AU  - Manson,Jean
TI  - Predicting TSE transmission
T2  - Prions and amyloids : self-propagating protein structures in mammals, yeast and fungi,
PY  - 2008///
CY  - London
PB  - Henry Stewart Talks
KW  - Amyloid
KW  - Prions
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: The TSEs continue to pose a problem to animal and human health -- The vCJD epidemic appears to be in decline but new risks of human to human transmission are now apparent -- Chronic wasting disease is a major problem currently in the US although its presence has not yet been detected in Europe -- Predicting and preventing transmission of disease requires an understanding of the routes of transmission within and between animals and the host factors which determine susceptibility -- We have studied natural disease and both in vivo and in vitro model systems to unravel the basic mechanisms of disease -- PrP protein has a central role in the outcome disease and mutations and polymorphisms in host PrP can profoundly alter the host's susceptibility to a TSE agent -- Precisely how host PrP influences the outcome of disease has not been established -- Both mutations and glycosylation can profoundly influence transmission both within and between species; Access restricted to subscribers
UR  - https://hstalks.com/bs/952/
UR  - https://hstalks.com/bs/p/282/
ER  -