TY - ADVS AU - Kent,Stephen B.H. TI - Solid-phase peptide synthesis T2 - Chemical biology : the role of chemistry in our fundamental understanding of biology, PY - 2008/// CY - London PB - Henry Stewart Talks KW - Biology KW - Chemistry N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Chemical structure of peptides -- Chemical peptide synthesis -- Classical solution synthesis -- Solid-phase peptide synthesis -- Chemistry of SPPS -- Automated solid-phase peptide synthesis -- Impact of SPPS -- Fundamentals of SPPS -- Synthesis takes place within the beads -- 'Super-elastic' swelling of peptide-resin beads -- Boc chemistry SPPS -- Fmoc chemistry SPPS -- 'Difficult' peptide sequences in SPPS -- Optimized solid-phase peptide synthesis -- Impact on SPPS of modern analytical methods -- Extensions of SPPS & applications of the solid-phase principle -- Scope and limitations of SPPS -- Impact of chemical ligation -- Total synthesis of human lysozyme; Access restricted to subscribers UR - https://hstalks.com/bs/932/ UR - https://hstalks.com/bs/p/279/ ER -