TY - ADVS AU - Grune,Tilman TI - Protein oxidation and removal of oxidized proteins by proteolysis T2 - Free radicals and the oxygen paradox : oxidative stress in biology, aging and disease, PY - 2007/// CY - London PB - Henry Stewart Talks KW - Free Radicals KW - Oxidative Stress N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Oxidized proteins -- Intracellular proteases -- The 20S core proteasome -- Proteasomal particles -- The proteasome-ubiquitin system -- Protein oxidation and proteasome -- Degradation of oxidized proteins and protein function -- Protein surface hydrophobicity -- Unfolding of oxidized proteins -- Stability of the 20S proteasome towards oxidation -- Oxidative stress and protein turnover -- Oxidation-induced proteolysis -- Degradation of oxidized proteins in cells -- What happens if degradation fails? -- Protein aggregates inhibit the proteasome -- Particle uptake by fibroblasts; Access restricted to subscribers UR - https://hstalks.com/bs/383/ UR - https://hstalks.com/bs/p/21/ ER -