TY - ADVS AU - Wilson,Daniel N. TI - Antibiotic inhibition of ribosome function T2 - The mechanisms of ribosome function : insights into protein synthesis, PY - 2008/// CY - London PB - Henry Stewart Talks KW - Protein Biosynthesis KW - Ribosomal Proteins KW - Ribosomes N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Overview of antibiotics that target the ribosome -- Different mechanisms by which translation initiation inhibitors, such as kasugamycin and edeine, perturb initiator tRNA binding -- Structural insight into how the thiopeptide class of antibiotics, such as thiostrepton and micrococcin, inhibit stable binding of translation factors, such as EF-G, to the ribosome -- Mechanism by which drugs, such as chloramphenicol and macrolides inhibit the peptidyltransferase reaction -- How species specific differences in antibiotic interaction sites between different organisms can have a dramatic influence on drug binding; Access restricted to subscribers UR - https://hstalks.com/bs/812/ UR - https://hstalks.com/bs/p/285/ ER -