TY  - ADVS
AU  - Olson,Steven T.
TI  - Regulation of blood coagulation by the serpin, antithrombin
T2  - Protein epidemiology : understanding human diseases at the level of protein structure and function,
PY  - 2007///
CY  - London
PB  - Henry Stewart Talks
KW  - Antithrombins
KW  - Hemostasis
KW  - Protein Conformation
KW  - Proteins
KW  - Serpins
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Antithrombin and hemostasis -- Dysfunctional antithrombins and thrombophilia -- Protease regulation by serpins -- Heparin requirement for antithrombin function -- Structural determinants of heparin binding to antithrombin -- Heparin-induced conformational changes in antithrombin -- Heparin as an allosteric activator of antithrombin -- Bridging and conformational change mechanisms of heparin activation of antithrombin -- Structural basis of conformational activation -- Role of exosites in conformational activation -- Role of the reactive loop in antithrombin anticoagulant function -- Implications for improved heparin anticoagulants; Access restricted to subscribers
UR  - https://hstalks.com/bs/64/
UR  - https://hstalks.com/bs/p/33/
ER  -