TY - ADVS AU - Sugden,Mary TI - Modifications of pyruvate handling in health and disease T2 - Protein epidemiology : understanding human diseases at the level of protein structure and function, PY - 2007/// CY - London PB - Henry Stewart Talks KW - Protein Conformation KW - Proteins KW - Pyruvic Acid N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Potential metabolic fates of pyruvate -- Lactate transport -- Role of pyruvate dehydrogenase complex (PDC) -- Regulation of PDC -- Mechanisms of activation of PDC by pyruvate dehydrogenase phosphatases -- Pyruvate dehydrogenase kinase (PDK) expression and regulation -- Multi-site phosphorylation -- Transcription factors regulating PDK4 expression -- Anaplerosis and cataplerosis -- Pyruvate carboxylase -- Insulin secretion and action -- Glucose/fatty-acid cycle -- Consequences of PDK4 upregulation -- Disorders of pyruvate handling; Access restricted to subscribers UR - https://hstalks.com/bs/45/ UR - https://hstalks.com/bs/p/33/ ER -