TY - ADVS AU - Sly,William S. TI - Genetic disorders of carbonic anhydrases II and IV T2 - Protein epidemiology : understanding human diseases at the level of protein structure and function, PY - 2007/// CY - London PB - Henry Stewart Talks KW - Carbonic Anhydrases KW - genetics KW - Protein Conformation KW - Proteins N1 - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: Carbonic anhydrase deficiencies -- History of the disease -- Roles of CA II and IV in disease -- Sulfonamide inhibitors for treatment of some disorders -- Characterization of CA isozymes -- CA IV discovery and function -- Mouse knockout models of CA deficiencies -- CA IV, unfolded protein response and retinitis pigmentosa -- ER stress and apoptosis in the choriocapillaris -- Chemical chaperones and treatment of retinitis pigmentosa -- Future studies; Access restricted to subscribers UR - https://hstalks.com/bs/71/ UR - https://hstalks.com/bs/p/33/ ER -