TY  - ADVS
AU  - Mohammadi,Moosa
TI  - Structural basis for Fibroblast Growth Factor (FGF) receptor activation: implications in development and disease 
T2  - Signal transduction via protein tyrosine kinase receptors : structures, function, regulation, mechanisms and role in disease,
PY  - 2007///
CY  - London
PB  - Henry Stewart Talks
KW  - Receptor Protein-Tyrosine Kinases
KW  - Signal Transduction
N1  - Animated audio-visual presentation with synchronized narration; Title from title frames; Contents: FGF family of ligands, and FGF receptor (FGFR) subfamily of receptor tyrosine kinase superfamily -- The roles of FGF signaling in mammalian biology and diseases -- FGFR receptor alternative splicing and its essential role in epithelial-mesenchymal signaling loop, and organogenesis -- Structural mechanism by which FGF and heparan sulfate induce FGFR dimerization and activation on the cell surface -- A working model for FGFR autoinhibition -- Structural mechanisms by which FGF-FGFR binding specificity is achieved -- Structural basis for how alternative splicing regulates ligand-binding specificity of FGFRs -- Structural basis by which ligand-dependent pathogenic mutations in FGFR lead to receptor gain-of-function in human skeletal syndromes -- Structural basis by which alternative splicing regulates patterning ability of FGF8 in the brain; Access restricted to subscribers
UR  - https://hstalks.com/bs/455/
UR  - https://hstalks.com/bs/p/38/
ER  -